• Low-Dose Orlistat Enhances Oxaliplatin Response in Colorecta

  2026-06-03

  The reference study demonstrates that low-dose orlistat, a fatty acid synthase inhibitor, significantly enhances the therapeutic efficacy of oxaliplatin in colorectal cancer models by promoting synergistic apoptosis. These findings offer a promising strategy to overcome chemoresistance and improve outcomes in advanced colorectal cancer.

• Cy7 NHS Ester: Protocols and QC for Near-Infrared Biomolecul

  2026-06-03

  Cy7 NHS ester (A8109) addresses the need for gentle, water-based near-infrared labeling of proteins and peptides, enabling sensitive fluorescent detection without the drawbacks of organic solvents or excessive dye quenching. It is best suited for workflows requiring high solubility and rapid conjugation but is not appropriate for applications demanding long-term storage of dye solutions or labeling in strictly non-aqueous environments.

• 4-Hydroxytamoxifen: Technical Guidance for Research Workflow

  2026-06-02

  4-Hydroxytamoxifen is a potent estrogen receptor modulator optimized for DMSO-based workflows, supporting applications in breast cancer, prostate cancer, and cardiac myocyte research. Researchers should avoid protocols requiring aqueous or ethanol solubility and adhere to strict storage conditions to maintain reagent integrity and experimental reproducibility.

• HyperFusion High-Fidelity DNA Polymerase: Accelerating Neuro

  2026-06-02

  HyperFusion™ high-fidelity DNA polymerase delivers unmatched fidelity and inhibitor resistance for challenging PCR, including GC-rich templates and long amplicons. Its unique fusion design streamlines workflows in neurodegeneration and developmental genetics, producing reliable results where standard enzymes fail.

• Calpeptin as a Calpain Inhibitor: Optimizing Pulmonary Fibro

  2026-06-01

  Calpeptin stands out as a nanomolar-potency calpain inhibitor, enabling precise modulation of cell differentiation and fibrotic pathways in advanced pulmonary fibrosis models. This article delivers applied protocols, troubleshooting insights, and comparative perspectives, empowering researchers to maximize reproducibility and translational value in fibrosis and inflammation studies.

• G007-LK Tankyrase 1/2 Inhibitor: Precision Control of Wnt/β-

  2026-06-01

  Discover how G007-LK, a potent tankyrase 1/2 inhibitor, enables precise modulation of Wnt/β-catenin signaling in APC mutation colorectal cancer research. This article delivers a unique focus on assay design, mechanistic insights, and optimized protocols for cancer biology.

• AM251 (SKU B1427): Enhancing CB1 Antagonist Assay Reliabilit

  2026-05-31

  This scenario-driven guide demonstrates how AM251 (SKU B1427), a potent CB1 receptor antagonist, empowers cell viability, apoptosis, and neuropharmacology workflows with reproducibility and quantitative rigor. Drawing on real laboratory challenges, the article details best practices and protocol optimization for AM251 use, supporting data-backed decisions in cannabinoid receptor research and related fields.

• TaqI Restriction Endonuclease: Practical Protocol and QC Gui

  2026-05-30

  TaqI Restriction Endonuclease provides rapid, sequence-specific cleavage of plasmid, PCR, and genomic DNA in research workflows, supporting applications such as cloning and DNA fragment analysis. It is not suitable for diagnostic or clinical purposes, but its protocol efficiency and built-in tracer dyes streamline routine molecular biology procedures.

• CCK-8 in Cancer Apoptosis Research: Assay Precision & New In

  2026-05-29

  Explore how the Cell Counting Kit-8 (CCK-8) enables precise cell viability measurement in apoptosis-driven cancer research. This article reveals unique, evidence-based applications and assay strategies not covered elsewhere.

• Targeted mRNA Nanoparticles Restore BBB after Ischemic Strok

  2026-05-29

  This study introduces a lipid nanoparticle system for targeted mRNA delivery that promotes neuroprotection after ischemic stroke by modulating microglial polarization. The findings demonstrate effective restoration of the blood-brain barrier and attenuation of poststroke neurological deficits, with implications for advancing mRNA therapeutics in neurovascular disease models.

• HyperFusion High-Fidelity DNA Polymerase: Precision in Neuro

  2026-05-28

  HyperFusion™ high-fidelity DNA polymerase redefines PCR workflows for complex neurogenetics, excelling in the amplification of GC-rich and long templates. Its superior accuracy and inhibitor tolerance empower researchers tackling advanced cloning, genotyping, and high-throughput sequencing—especially in challenging contexts like neurodegeneration research.

• Sulfo-NHS-SS-Biotin: Disulfide-Based Protein Labeling for Dy

  2026-05-28

  Explore the biotin disulfide N-hydroxysulfosuccinimide ester Sulfo-NHS-SS-Biotin and its pivotal role in advanced protein labeling for affinity purification. This article uniquely connects cutting-edge lysosomal research to practical assay optimization using Sulfo-NHS-SS-Biotin.

• Superoxide Dismutase (SOD) Activity Assay Kit: Practical Use

  2026-05-27

  The Superoxide Dismutase (SOD) Activity Assay Kit (SKU K2035) enables quantitative, colorimetric measurement of SOD enzyme activity in biological fluids, addressing the need for reliable detection of antioxidative defense in oxidative stress studies. It is suitable for research applications but should not be used for diagnostic or clinical purposes.

• DFCP1 Modulates Starvation-Induced ATGL Activity in Lipid Dr

  2026-05-27

  The reference study uncovers Double FYVE Domain Containing Protein 1 (DFCP1) as a nutrient-sensitive regulator of adipose triglyceride lipase (ATGL)-mediated lipid droplet lipolysis during cellular starvation. This mechanistic insight advances understanding of lipid storage homeostasis, with practical implications for metabolic disease research and protein stability protocols.

• GPNMB-Based Multimodal Model Predicts ESCC Immunotherapy Res

  2026-05-26

  This study establishes a clinically scalable model that integrates circulating GPNMB levels with tumor microenvironment features to predict immunotherapy response in esophageal squamous cell carcinoma (ESCC). The findings clarify mechanisms of immune resistance and offer a robust framework for patient stratification prior to immune checkpoint inhibitor therapy.

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