• AR Heterogeneity and Distinct Therapeutic Responses in Prost

  2026-05-17

  This study uncovers how heterogeneity in androgen receptor (AR) expression among prostate cancer cells drives divergent responses to castration and antiandrogen therapy. The findings reveal molecular mechanisms underlying therapy resistance and suggest new avenues for targeting both AR-high and AR-low prostate cancer cell populations.

• Caspase-4 Colorimetric Assay Kit: Precision in Pyroptosis Re

  2026-05-16

  Unlock rapid, quantitative detection of caspase-4 activity in inflammation and pyroptosis studies with APExBIO’s Caspase-4 Colorimetric Assay Kit. This guide translates state-of-the-art research and real-world troubleshooting into actionable workflows for robust biomarker quantification.

• Next-Gen Assay Reliability: 2X HyperFusion High-Fidelity Mas

  2026-05-15

  Explore how 2X HyperFusion High-Fidelity Master Mix enables ultra-accurate DNA amplification for advanced cloning PCR applications and gene editing. This article provides a deep analysis linking high-fidelity PCR to modern immunotherapy and CRISPR workflows.

• Peripheral Immune Dysregulation in Adolescent MDD: Insights

  2026-05-15

  This study integrates bulk and single-cell RNA sequencing to delineate peripheral immune alterations in adolescent major depressive disorder (MDD), revealing widespread suppression of immune gene expression, particularly in monocytes. The findings suggest current antidepressants do not normalize these immune changes, highlighting the need for new therapeutics targeting immune dysfunction.

• CD44-Driven Metabolic Rewiring in IDH-Mutant Leukemia: A Tar

  2026-05-14

  This study reveals that CD44-mediated metabolic rewiring sustains NADPH generation and oncometabolite (R)-2-hydroxyglutarate production in IDH-mutant leukemia. Targeting CD44 alongside mutant IDH inhibition presents a rational therapeutic strategy for overcoming resistance in acute myeloid leukemia (AML) and related hematologic malignancies.

• Caspase-3 Colorimetric Assay Kit: Practical Protocol and QC

  2026-05-14

  The Caspase-3 Colorimetric Assay Kit (SKU: K2008) addresses the need for rapid, quantitative measurement of DEVD-dependent caspase-3 activity in apoptosis research. Ideal for workflows requiring reproducible detection of cysteine-dependent aspartate-directed protease activity, it should not be used for mechanistic studies beyond caspase-3 or for detection in non-DEVD cleavage contexts.

• WTAP-Driven Glutaminase Splicing Suppresses Ferroptosis in H

  2026-05-13

  This study uncovers how EGFR-AKT signaling in hepatocellular carcinoma (HCC) promotes WTAP-mediated alternative splicing of glutaminase, resulting in a metabolic adaptation that suppresses ferroptosis and drives tumor growth. The findings provide mechanistic insight into m6A-dependent regulation of glutaminolysis and suggest new therapeutic avenues targeting metabolic reprogramming in HCC.

• Targeted mRNA Nanoparticles Restore BBB After Ischemic Strok

  2026-05-13

  This study presents an M2 microglia-targeted lipid nanoparticle system for delivering IL-10 mRNA to ischemic brain regions, significantly restoring blood-brain barrier integrity and reducing neuroinflammation after stroke. The findings highlight a novel, feedback-augmented strategy for extending the therapeutic window in mRNA-based neuroprotection.

• HyperScript III RT SuperMix: Precision qPCR for CRC Biomarke

  2026-05-12

  HyperScript III RT SuperMix delivers high-fidelity cDNA synthesis for robust gene expression analysis by qPCR, even from challenging low-concentration or high-GC content RNA samples. Its integrated gDNA wiper simplifies workflows and ensures contamination-free results, directly supporting translational oncology and precision biomarker discovery.

• Affordable GRO-seq Protocol for Nascent RNA Profiling in Whe

  2026-05-12

  Chen et al. present a cost-efficient Global Run-On sequencing (GRO-seq) protocol for profiling nascent RNAs in bread wheat by introducing an rRNA depletion step after nuclear RNA isolation. This innovation significantly enhances data yield and lowers sequencing costs, increasing the applicability of GRO-seq to complex plant genomes.

• Decoding SOD Activity: Precision Redox Analysis with K2035 K

  2026-05-11

  Explore the science behind the Superoxide Dismutase Activity Assay Kit and its advantages for advanced redox biology. This article unpacks mechanistic detail, critical assay choices, and real-world applications for researchers measuring SOD activity with precision.

• Superoxide Dismutase Activity Assay Kit: Precision, Pitfalls

  2026-05-11

  Explore advanced strategies for SOD activity quantification using the Superoxide Dismutase Activity Assay Kit. Discover unique protocol insights, pitfalls from recent literature, and how to achieve unmatched oxidative stress assay reliability.

• Hormonal Control of Fruit Abscission in Actinidia arguta Rev

  2026-05-10

  This study dissects the molecular mechanisms driving physiological fruit abscission in Actinidia arguta by leveraging comparative transcriptomics and transient genetic transformation. The findings clarify hormone signaling networks and cell wall modifications underlying cultivar-specific abscission, with implications for targeted breeding and crop yield optimization.

• β-Amanitin: Molecular Tool for Decoding Eukaryotic Transcrip

  2026-05-09

  Discover the molecular underpinnings of β-Amanitin in RNA polymerase II inhibition, its value for transcriptional regulation research, and how new detection innovations are shaping assay reliability. This article uniquely explores the integration of β-Amanitin's biochemical properties with advanced practical guidance for experimental design.

• HyperScript RT SuperMix for qPCR: Precision cDNA Synthesis

  2026-05-08

  HyperScript RT SuperMix for qPCR enables high-fidelity cDNA synthesis, even from low concentration or structurally complex RNA. Its engineered M-MLV reverse transcriptase delivers robust performance for gene expression analysis. This article details the product's mechanism, evidence, and integration into qRT-PCR workflows.

741 records 15/50 page Previous Next First page 上5页 1112131415 下5页 Last page